1. Coriolus versicolor, also known as Coriolus down mining, food for a long time to build refined gas, Kennedy is the bones of superior light Yannian, have to increase the body's immune system function, you can enhance the body's disease-resistant capacity.

2. Efficacy of polysaccharide

Versicolor PSK extract is the main active ingredient: the molecular weight of more than 100,000, which is rich in β-(1 → 3) glucoside bond glucan, and is measured β (1 → 3) and β (1 → 6) glycosidic bond. Another mannose, and xylose, galactose, arabinose and rhamnose. At the same time, a combination of polysaccharide chain of small protein molecules (peptides) composed of proteoglycan (psp), it is a polysaccharide oral effective clinical treatment for chronic hepatitis B, alcoholic liver, strengthening the digestive system, Lung and cervix, breast cancer, and other parts of the role of radiotherapy and chemotherapy can significantly improve the patient's immune cell function and humoral immune function, enhance the body's tolerance of chemotherapy to reduce the infection and bleeding, to improve the quality of life for patients.

1. Ancient pharmacology

Chinese medicine has long used versicolor record against cancer, has a good clinical effect, especially for the treatment of cancer, the results are obvious. As for lung cancer, bronchitis cases and bronchodilators are not without effect. Eastern Han Dynasty, "Shen Nong's Herbal Classic" has been recorded by cancer versicolor, when the cancer is called 'pain swelling', physicians will versicolor to strengthen the resistance of the human body, the treatment of cancer. Li Shizhen of the Ming Dynasty, "Compendium of Materia Medica" and the records have described have versicolor soothe the nerves, longevity, Lee joints, bones Kennedy, the role of the rule deafness. Japanese versicolor from the mycelium extract of sugar versicolor (PS-K) as anti-cancer drug in Japan in the open market sales.

2. Modern pharmacology

Modern scientists have confirmed that the versicolor can improve the human immune, endocrine regulation, to improve the swelling of Human Organ functions, such as the central nervous, circulatory, respiratory, liver, have good regulation and protection. For cancer, it is more effective in inhibiting cancer cell proliferation and tumor swell, can reduce the side effects.

Recently found that the wild versicolor-effective in containing extract of leukemia (that is, cancer of the blood), lung cancer, breast cancer, colorectal cancer and direct the growth of cancer cells, leukemia and liver cancer cells by inhibiting the growth of the most obvious effect, the percentage as high as the effectiveness of Of 90, at the same time can raise the individual immunity. In addition to cancer, scientists versicolor also confirmed that the A-type embryos to help prevent cancer.

Modern medicine and pharmacology studies have shown that versicolor from the fruiting body, mycelia, the broth to extract the polysaccharides, are strong tumor suppressor activity, and in Japan as an anti-cancer drugs. In addition to the home for hepatitis, but also on trial for the prevention and treatment of liver cancer, and achieved satisfactory results. Chronic bronchitis, chronic active hepatitis, and so have a good effect. China has developed a "liver-versicolor" and other preparations for the clinical.

On immune function:

(1) animal experiments show that the PSK 180 Mouse sarcoma of the peritoneal macrophage function to promote a significant role.

(2) so that the rabbits on sheep red blood cells to generate antibodies increased.

(3) can stimulate the growth of in vitro human lymphoblastic transformation.

(4) use of the treatment of cancer patients (including chemotherapy with the drug users) can promote cellular immunity, such as the promotion of the PHA conversion rate lymphocyte, so that the rosette formation rate of increase (p <0.01), Tuberculin test negative from positive, weakly positive to strongly positive, and so on. At the same time, there are antibody-producing, such as IgG make up, IgG decline in the use of the treatment of chronic bronchitis, also double-stranded enzyme skin test, the tuberculin skin test, phytohemagglutinin skin test, roses And so enhance the rate of node formation.

A Tesuo abroad (ATSO, from versicolor polysaccharide extracted to the main and a small amount of protein-containing products), immune function also significantly enhance the role, such as hard-drive (Picrylchloride) and the tuberculin Delayed reaction to the promotion of the role; combination with other anti-cancer drugs, according to the 100 mg / kg oral, to prevent cyclic amines, mitomycin C, 5 - Primisulfuron ingot caused by the immunosuppressive effects. In addition, the sensitized animals plaque and a number of antibodies produced significant role in the promotion. Clinical and Lin Wan-sharing network the treatment of sarcoma cells, showing a significant increase in the number of lymphocytes, B cell surface Ig also close to normal activity.

Another versicolor preparation of PS-K (versicolor extracted from the preparation of a polysaccharide protein) can also enhance the immune function, so that both animals with tumor xenograft of the red blood cell antibodies produced by inhibiting recovery, but also So that the tumor with surgery, chemotherapy, radiation caused by the delay skin graft rejection have been restored, in vitro can promote the transformation of lymphoid cells.

Anti-tumor effects: PSK, ATSO, PS-K on a variety of experimental animals must have a tumor inhibition. PSK used by the mice treated cancer cells and EAC's sarcoma 180 ascites tumor cells to mice inoculated, to more than 21 days without tumor growth. At this point a second vaccination, and the other in order to make the same health coverage in the control mice, the results of the treatment group compared with the control group, the inhibitory rate of 90%. ATSO used for the treatment of tumors in mice disappear, and then against sarcoma 180, Aldrin, and other solid tumors, most of the tumor in mice do not appear; with PMS (cultured mycelium polysaccharide versicolor) have the same role in the control group, there are Tumor growth.

Ganoderma lucidum and chemical often used in radiotherapy, to reduce fatigue, loss of appetite, hair loss, bone marrow and lack of side effects such as the risk of infection. Ganoderma lucidum can not only alleviate the pain, can also greatly improve the quality of life of cancer patients. Ganoderma lucidum can be used to build up their strength and enhance their ability to think and to prevent the forgetful, have been used in the treatment of liver disease, high blood pressure and arthritis.

Complement the impact of: ATSO in the test tube will enable the people of the fresh serum complement C3 conversion in immunoelectrophoresis in easy-to-mobile to the cathode, the convection in two-way electrophoresis in the C3 has been translated into 2 or 3 peak of the characteristics of the map Type, and has made it clear that C3 in vivo showed a similar activity.

Infection control: ATSO mice by intraperitoneal injection to prevent PR8 influenza virus infection. The influenza virus A2/Kumamoto to 3 times the lethal dose 50 (LD50) in mice sensitized with ATSO intranasal administration, but also a significant role in prolonging life. To the parainfluenza virus HVJ, by injection or intranasal administration to prevent infection. Of chicken infected with Japanese encephalitis virus, ATSO was also a significant preventive effect. PSK on a large number of rabbits infected with Staphylococcus aureus have some protective effect. Clinically, patients with leukemia on a significant role in the prevention of infection. However, no in vitro antibacterial activity. Accordingly, the prevention and treatment of infected materials are likely to enhance immune function.

Asthma: PSK on the guinea pig histamine has a protective effect on asthma.

Anti-cancer pharmacology:

1. Versicolor polysaccharide-protein (P SK) have been identified through enhanced tumor-specific function of disease-free and to play a role in cancer.

2. PSK can improve the tumor-bearing mice delayed skin hypersensitivity force.

3. PSK anti-tumor effect and I g G have the ability to restore the line.

4. -14 Pair of cervical cancer. -180 Sarcoma in mice. EAC. Lymphocytic leukemia cells -7212. Lymphocytic leukemia cells -388. Adenocarcinoma -755 and other laboratory animals have a tumor inhibition.

5. PS-K to 20mg / kg doses of mice Sarcoma -180 on the inhibitory rate of 70.2 to 77.5 percent, the rate of tumor elimination of 50 to 57%.

6. Versicolor polysaccharide-body (ATSO) of Switzerland mouse sarcoma -180 inhibition rate of 99.3 percent, the elimination rate of 100% of the tumor, a dose of 1mg / kg, administered intravenously for five days.

7. Chi vitro mycelium polysaccharide (Coriolan) of the strong anti-cancer effect, not only higher than ATSO, and more of Ganoderma lucidum. Umbellatus polysaccharides in the higher potency, the mice sarcoma -180 curb the rate of 99.9% , The extinction rate of 100% of the tumor.

8. ATSO cancer in mice inhibited the rate of 77.2, Coriolan compared with 80.9%; ATSO mice Shionogi cancer inhibition rate of 70.7% (female rats) and 69.2% (male rats), and the Coriolan were 82.1% and 76.4%.

1. For leukemia, lymphoma, gastric cancer, breast cancer, cervical cancer and other tumors, have a certain effect alone, with chemotherapy, radiation therapy, surgery and so on with the use of better efficacy. China Study Group use Baishan versicolor PSK injection combined with chemotherapy rule more than 100 cases of leukemia, can enhance the body's resistance to the chemotherapy, significantly reduced infection and bleeding, and enhance the effectiveness of chemotherapy, the remission rate increase, extension of the Survival.


XX such as the use of the city hospital treatment of 24 cases of leukemia (366, "ALL" 8 cases of "urgent single" 4 cases, "tablets of urgency" in 3 cases, "CML" 6 cases, the other 3 cases), full and part - Alleviate the level of 8 cases, 5 cases of partial remission secondary, not only ease 1, 2 cases of recurrence, the average survival time of 281 days; in the single-use chemical treatment in 10 cases (6 cases of acute single, ALL 1 , A CML, erythroleukemia 2), 5 cases of partial remission and 3 patients did not ease, the deterioration of 2 cases, the average survival period of 48 days, a significant difference between the two groups. PS-K treatment of 289 cases of a variety of tumors, in order to reduce the tumor for more than 25% of the total effective, efficient 21.5 percent, with cobalt 60 therapy of cervical cancer are up 65.9 percent efficiency.

2. Chronic bronchitis, such as: treatment of Versicolor alone 529 cases of chronic bronchitis, 20 days after treatment, effect more than accounted for 39.1 percent of the total effective rate 82.8%, cough, sputum, asthma has better curative effect. Children with spastic rule 124 cases of bronchitis, the cure rate of 48.4 percent in the near future, a significant 31.5 percent efficiency, with a total effective rate 87.1%.

3. Hepatitis: versicolor PSK or the treatment of persistent, chronic hepatitis Shubai Li, 2 to medication in June, marked the efficiency of 50% of the total effective rate in the 66 to 80%. After treatment, cells to enhance immune function, HbsAg positive review of the original 68 cases, 26 cases negative accounted for 38.2 percent.

4. Other: PSK treatment of 100 patients with low concentrations of alpha-fetoprotein-positive continued, taking 2 to 8 months, six months, 64 cases of conversion, 1 year conversion 55/79 cases (69.6%), negative 85% of those who appear effect in a month, 1-year follow-up of the 79 cases, 2 cases of liver cancer. PSK by injection in the treatment of chronic nephritis in 15 cases, 7 cases of valid and invalid 8 cases. Extract treatment Krestin with 36 cases of psoriasis, and white blood Ning treatment of 70 cases compared to similar effect, enhancing immune cells after treatment, IgA, IgG increased (p> 0.05 ~ 0.01). In addition, the fair trial in asthma, lupus erythematosus, rheumatism, rheumatoid, and other immune-related diseases.

In conclusion, many of the show:

(1). Not in the tumor prior to the transfer of the use of PSK, may have the effect of inhibiting tumor growth.

(2). Animals of the tumor, can PSK to repair and suppress the immune response. (3). PSK, when combined with chemotherapy drugs, PSK can enhance the activity of these drugs.

(4). Oral PSK with the results, so for a long time to consider the use of in order to maintain treatment.

To enhance immune function in human cells:

For the treatment of leukemia, can be seen lymphoblastic conversion and E rosette formation rate was significantly higher, can enhance the body's resistance to chemotherapy, to enhance the efficacy of chemotherapy.

Separate and thoracis trial in patients with lupus and, T cell immune function in a marked increase in three weeks. Combined with chemotherapy for many types of cancer and leukemia patients, most of the cases of T cell function have been restored, a significant improvement in clinical symptoms, no obvious infection and bleeding tendency.

To improve the symptoms of chronic hepatitis for effects, the better to reduce aminotransferase. The improvement in symptoms at the same time see E rosette forming cells and the conversion rate of increase in the PHA skin test and improve the intensity of the reaction.

In recent years, some people believe that the cellular immune dysfunction in chronic active hepatitis is a major factor in the formation, which is due to the lower T cell function, the B cells of a supporting role shortage, B cells can not produce enough antibodies to wipe out the virus; so that the liver cells Have been infected with the virus and develop into chronic hepatitis.

Baishan PSK burden of fungi polysaccharides, such as a clear role in the promotion of cellular immunity, and non-toxic, it is considered to be a good prevention and treatment of chronic hepatitis drug. In addition, children with acute lymphoblastic leukemia after the injection of the goods increased IgM can be seen, that also enhance the role of humoral immunity.