Anti-bacterial
- so far, Phellinus igniarius little anti-bacterial
research. In 2004, Korean scholars Jong Moon Hur,
and so on, using Extraction Phellinus igniarius
fruiting bodies were tested methanol, chloroform,
n-butyl alcohol and water extracts, a rate: 0.06%,
0.008%, O.016 % And O.026% (w / w), respectively,
and then twice with dilution method of Jixi Lin
methicillin-resistant Staphylococcus aureus (Methicillin-restant
Staphylococcus aureus) the minimum inhibitory concentration
(Minima in-hibitory concentration, MIC ), The results
show that: n-butyl alcohol extraction Jixi Lin-versus-methicillin-resistant
Staphylococcus aureus was the most effective (MIC
:63-125ug / mL), however, its principle of anti-bacterial
and anti-bacterial spectrum needed further study.
Cancer
- as early as 1968, the Japanese and so
on Ikekawa found that the yellow wild mulberry extract
of the fruit body of the S180 sarcoma in mice inhibition
rate of 95.7 percent. Sasaki found, such as Phellinus
igniarius played the role of the material for anti-cancer
polysaccharides.
Ajith studied, such as ethyl acetate Phellinus igniarius,
methanol and water extracts, and then were used
for anti-Dalton lymphatic cancer ascites (Dalton
s lymphoma ascites, DLA) and Ehrlich ascites carcinoma,
found that water does not extract their cytotoxic
effect , And the three extracts of DLA tumor cells
in mice caused a significant inhibition of growth
and the ethyl acetate extract of the best in 50mg/KG
dose of oral drug delivery and clinical standards
will be able to refer to drugs Cisplatin (cisplatin)
4mg/KG the effect of intravenous considerable. Cho,
JH, such as Phellinus igniarius found the anti-cancer
effects in vitro through the purification of extracellular
signal-regulated kinase enzymes and (ERK1 and p38MAPkinases)
and control the exchange of signals between cells,
which can prevent the proliferation of tumor cells.
Han SB, and so further study of the Phellinus igniarius
is the role of polysaccharide in tumor cells. Polysaccharide
found that administration of melanoma B16FlO transplant
survival rate of test mice significantly enhance
the role of NCI-H23 can inhibit cell growth and
reduce lung B16FlO the transfer of melanoma and
anti-cancer drugs doxorubicin and the anti-tumor
do By comparison, doxorubicin was found to prevent
the transfer of cancer cells than the effect of
polysaccharide Phellinus igniarius poor final results
showed that: Polysaccharides effective in containing
the growth of cancer cells and prevent their transfer
through the cell and the regulation of body fluids
and immune function, And normal fibroblasts not
cytotoxicity.
As a result, it can be said Phellinus igniarius
polysaccharide may be chemically and the ideal of
anti-cancer drug. In 2004, Kim, and other more mulberry
who studied the mechanism of anti-cancer polysaccharides,
made up of polysaccharide and the role of peritoneal
macrophages produce nitric oxide, tumor necrosis
factor and the impact of reactive oxygen free radicals
part of the day, or use different FITC-dextran as
a tracer. Analysis of the polysaccharides and polysaccharide
not on the peritoneal macrophages of the video part
of the day and found that increased phagocytosis,
and nitric oxide and tumor necrosis factor production
of polysaccharide and add a certain amount of concentration-dependent,
but No effect on reactive oxygen species.
As a result, it may be inferred that its anti-cancer
mechanism: by increasing the antigen may be a variety
of immune recognition and the necessary co-stimulatory
molecules as well as the histocompatibility complex
molecules between the role of antigen expression
has affected the course of the necessary number
of cells Surfactant molecules to indirect regulation
and control regulation of T-cell immunity against
cancer cells, and to achieve anti-cancer effect.
Anti-fibrosis
- Second Military Medical University,
Chang Wan and so on, the anti-fibrosis Phellinus
spurt line were studied. The use of carbon tetrachloride-induced
liver fibrosis in rats and watch Phellinus igniarius
of serum enzymes, protein level and composition
of collagen and hyaluronic acid laminin video
content part of the day. The results showed that:
Sang Huang to a significant reduction in liver
fibrosis serum amino transferase and the level
of serum collagen content of the ingredients.
And show Pathological observation of liver cells
Phellinus igniarius significant protective effect,
at the same time inhibit proliferation of fibrous
tissue, to prevent liver fibrosis formation and
development.
Then, they further study the regulation of Phellinus
igniarius and anti-liver fibrosis, the in vitro
human peripheral blood mononuclear cells, have
their test Phellinus igniarius r-enhancing effect
of interferon. The results showed that: Phellinus
igniarius significantly increased serum levels
of interferon-r-and dose-dependent manner. Thus
it can be said Phellinus igniarius has obvious
anti-hepatic fibrosis, and the r-interferon-induced
generation may be one of the mechanism.
Antioxidant
- South Korean scholars Ajith, TA, and
so on, the study of Phellinus igniarius -ethyl
acetate extraction of antioxidant found: the removal
of superoxide, ascorbic acid caused by inhibition
of lipid oxidation, and a peroxide oxidation Nitrogen
to remove the very good results.
At the same time, Mi-Yae Shon, and so on, respectively,
with methanol and hot water extraction from the
mulberry extract the yellow phenolic compounds,
a rate of 33.3mg/mL and 20.7mg/100mL, the use
of B-carotene - linoleic acid ester model Reactive
oxygen species and have a response system to test
anti-oxidation and free radical scavenging capacity,
measured hydroxyl radical, hydrogen peroxide just
in the clearance rate of 80% - 90%. However, it
may be due to its anti-cancer effect of the very
good reason or other, for its antioxidant role
in the relatively less on research.
Other pharmacological effects
- Phellinus igniarius is an Asian (especially
China, South Korea and Japan) of traditional Chinese
medicine, with people in general, used to treat:
stomach pain, gastrointestinal disorders, inflammation
of lymph cancer, as well as keeping fit, The prevention
of various diseases. Until recent decades, the
pharmacological effects only gradually scientific
explanation, in 1996, South Koreans Kim, HM, and
so on, from the isolated Phellinus igniarius polysaccharide,
and found it to stimulate conditioning and humoral
immune cells immunomodulatory activity , Which
releases a lot of products to stimulate immunity.
In addition, Phellinus igniarius on anti-inflammatory
role, Kim, SH, and so on, found that Phellinus
igniarius n-butyl alcohol extract can be eliminated
by the croton oil-induced mouse ear inflammation
of the edema, can strongly inhibit CAM angiogenesis,
and also found The extract also has analgesic
effect.
Phellinus igniarius is known to be anti-cancer
effect of higher fungi in the best fungi
its anti-cancer mechanism has gradually been recognized,
together with deep-seated culture of the reported
success, so the market is very optimistic about
the prospects. South Korea's Phellinus igniarius
fruiting body has been valuable as a medicine
for sale, its price up to 2300 U.S. dollars /
kg; Phellinus igniarius in Japan have begun to
enter the medical market. Despite the application
of SANG China's Huang has treated more than 2,000
years of history ( "Shen Nong's Herbal Classic"
mentioned, but clearly in the "Compendium
of Materia Medica"), but the slow development
of the market, may be the most important reason
is Its lack of depth study of pharmacological
effects.
As a result, Phellinus igniarius to the market
as soon as possible, and we inherit and carry
forward China's application of SANG Huang and
production experience, to strengthen its chemistry,
pharmacology, the development of new products,
new markets, our products to the world Phellinus
igniarius. To contribute to human health.
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